Metastatic Medullary Thyroid Cancer, Somatostatin Analogues and Markers
نویسندگان
چکیده
1Oncologia Medica 2, Istituto Oncologico Veneto IRCCS, Italy 2Clinica Chirurgica 2, Università degli Studi di Padova, Italy 3Qualità Accreditamento e Controllo interno, Istituto Oncologico Veneto IRCCS, Italy 4Otorinolaringoiatria, Dipartimento di Neuroscienze, Università degli Studi di Padova, Italy 5Anatomia Patologica e Citodiagnostica, Dipartimento di Medicina, Università degli Studi di Padova, Italy 6Radioterapia, Istituto Oncologico Veneto IRCCS, Italy 7Radiologia, Istituto Oncologico Veneto IRCCS, Italy 8Cardiologia, Istituto Oncologico Veneto IRCCS, Italy 9Radiation Oncology Department, Iaso Hospital, Greece 10Medicina Nucleare 1, Azienda Ospedaliera di Padova, Italy
منابع مشابه
Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine tumors.
Somatostatin (SS) and SS analogues inhibit the growth of various kinds of endocrine and exocrine cells via the SS receptor (SSTR). Carcinoid tumor is representative of the tumors treatable by SS analogues. We examined the expression of SSTR2A by immunohistochemical and in situ hybridization methods with a specific antibody against a synthesized 20-amino acid peptide of the COOH terminus of huma...
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Neuroendocrine tumours are a heterogeneous group including, for example, carcinoid, gastroenteropancreatic neuroendocrine tumours, pituitary tumours, medullary carcinoma of the thyroid and phaeochromocytomas. They have attracted much attention in recent years, both because they are relatively easy to palliate and because they have indicated the chronic effect of the particular hormone elevated....
متن کاملSomatostatin receptor expression in non-medullary thyroid carcinomas.
OBJECTIVE Peptide receptor radionuclide therapy (PRRT) is dependent upon binding of radiolabelled peptides to their respective receptor expressing cells. The main objective of this study was to characterize the expression of somatostatin receptor (SSTR) subtypes in non-medullary thyroid cancers in order to be able to recommend the use of PRRT as a treatment option in patients with progressive l...
متن کاملClinical comments related to medullary thyroid cancer diagnosis and management
BACKGROUND The American Thyroid Association (ATA) and more recently the European Thyroid Association (ETA) Guidelines on diagnosis and treatment of medullary thyroid carcinoma (MTC) have provided an excellent tool which was formerly lacking in the field of management of MTC. However, some relevant clinical questions, as the use of somatostatin analogues in the treatment of MTC and the managemen...
متن کاملExpression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization.
Somatostatin receptor gene expression of SSTR1, SSTR2, and SSTR3 subtypes was evaluated by in situ hybridization in 55 human primary tumors shown to contain a high density of somatostatin receptors in binding assays. All 55 tumors expressed at least one SSTR subtype. Of 55 somatostatin receptor-positive tumors, 46 had SSTR2 mRNA; all 46 were characterized as having receptors with a high affinit...
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